tRNA production links nutrient conditions to the onset of sexual differentiation through the TORC1 pathway.
Identifieur interne : 000416 ( Main/Exploration ); précédent : 000415; suivant : 000417tRNA production links nutrient conditions to the onset of sexual differentiation through the TORC1 pathway.
Auteurs : Yoko Otsubo [Japon] ; Tomohiko Matsuo [Japon] ; Akiko Nishimura [Japon] ; Masayuki Yamamoto [Japon] ; Akira Yamashita [Japon]Source :
- EMBO reports [ 1469-3178 ] ; 2018.
Descripteurs français
- KwdFr :
- ARN de transfert (génétique), Azote (métabolisme), Complexe-1 cible mécanistique de la rapamycine (génétique), Différenciation sexuelle (génétique), Nutriments (génétique), Nutriments (métabolisme), Phosphorylation (MeSH), Prolifération cellulaire (génétique), Régulation de l'expression des gènes fongiques (MeSH), Schizosaccharomyces (croissance et développement), Schizosaccharomyces (génétique), Schizosaccharomyces (métabolisme), Transduction du signal (génétique).
- MESH :
- croissance et développement : Schizosaccharomyces.
- génétique : ARN de transfert, Complexe-1 cible mécanistique de la rapamycine, Différenciation sexuelle, Nutriments, Prolifération cellulaire, Schizosaccharomyces, Transduction du signal.
- métabolisme : Azote, Nutriments, Schizosaccharomyces.
- Phosphorylation, Régulation de l'expression des gènes fongiques.
English descriptors
- KwdEn :
- Cell Proliferation (genetics), Gene Expression Regulation, Fungal (MeSH), Mechanistic Target of Rapamycin Complex 1 (genetics), Nitrogen (metabolism), Nutrients (genetics), Nutrients (metabolism), Phosphorylation (MeSH), RNA, Transfer (genetics), Schizosaccharomyces (genetics), Schizosaccharomyces (growth & development), Schizosaccharomyces (metabolism), Sex Differentiation (genetics), Signal Transduction (genetics).
- MESH :
- chemical , genetics : Mechanistic Target of Rapamycin Complex 1, RNA, Transfer.
- genetics : Cell Proliferation, Nutrients, Schizosaccharomyces, Sex Differentiation, Signal Transduction.
- growth & development : Schizosaccharomyces.
- chemical , metabolism : Nitrogen, Nutrients, Schizosaccharomyces.
- Gene Expression Regulation, Fungal, Phosphorylation.
Abstract
Target of rapamycin (TOR) kinase controls cell growth and metabolism in response to nutrient availability. In the fission yeast Schizosaccharomyces pombe, TOR complex 1 (TORC1) promotes vegetative growth and inhibits sexual differentiation in the presence of ample nutrients. Here, we report the isolation and characterization of mutants with similar phenotypes as TORC1 mutants, in that they initiate sexual differentiation even in nutrient-rich conditions. In most mutants identified, TORC1 activity is downregulated and the mutated genes are involved in tRNA expression or modification. Expression of tRNA precursors decreases when cells undergo sexual differentiation. Furthermore, overexpression of tRNA precursors prevents TORC1 downregulation upon nitrogen starvation and represses the initiation of sexual differentiation. Based on these observations, we propose that tRNA precursors operate in the S. pombe TORC1 pathway to switch growth mode from vegetative to reproductive.
DOI: 10.15252/embr.201744867
PubMed: 29330317
PubMed Central: PMC5836105
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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(genetics)</term><term>Gene Expression Regulation, Fungal (MeSH)</term><term>Mechanistic Target of Rapamycin Complex 1 (genetics)</term><term>Nitrogen (metabolism)</term><term>Nutrients (genetics)</term><term>Nutrients (metabolism)</term><term>Phosphorylation (MeSH)</term><term>RNA, Transfer (genetics)</term><term>Schizosaccharomyces (genetics)</term><term>Schizosaccharomyces (growth & development)</term><term>Schizosaccharomyces (metabolism)</term><term>Sex Differentiation (genetics)</term><term>Signal Transduction (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN de transfert (génétique)</term><term>Azote (métabolisme)</term><term>Complexe-1 cible mécanistique de la rapamycine (génétique)</term><term>Différenciation sexuelle (génétique)</term><term>Nutriments (génétique)</term><term>Nutriments (métabolisme)</term><term>Phosphorylation (MeSH)</term><term>Prolifération cellulaire (génétique)</term><term>Régulation de l'expression des gènes fongiques (MeSH)</term><term>Schizosaccharomyces (croissance et développement)</term><term>Schizosaccharomyces (génétique)</term><term>Schizosaccharomyces (métabolisme)</term><term>Transduction du signal (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Mechanistic Target of Rapamycin Complex 1</term><term>RNA, Transfer</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Schizosaccharomyces</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cell Proliferation</term><term>Nutrients</term><term>Schizosaccharomyces</term><term>Sex Differentiation</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Schizosaccharomyces</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN de transfert</term><term>Complexe-1 cible mécanistique de la rapamycine</term><term>Différenciation sexuelle</term><term>Nutriments</term><term>Prolifération cellulaire</term><term>Schizosaccharomyces</term><term>Transduction du signal</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Nitrogen</term><term>Nutrients</term><term>Schizosaccharomyces</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Azote</term><term>Nutriments</term><term>Schizosaccharomyces</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Gene Expression Regulation, Fungal</term><term>Phosphorylation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Phosphorylation</term><term>Régulation de l'expression des gènes fongiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Target of rapamycin (TOR) kinase controls cell growth and metabolism in response to nutrient availability. In the fission yeast <i>Schizosaccharomyces pombe,</i> TOR complex 1 (TORC1) promotes vegetative growth and inhibits sexual differentiation in the presence of ample nutrients. Here, we report the isolation and characterization of mutants with similar phenotypes as TORC1 mutants, in that they initiate sexual differentiation even in nutrient-rich conditions. In most mutants identified, TORC1 activity is downregulated and the mutated genes are involved in tRNA expression or modification. Expression of tRNA precursors decreases when cells undergo sexual differentiation. Furthermore, overexpression of tRNA precursors prevents TORC1 downregulation upon nitrogen starvation and represses the initiation of sexual differentiation. Based on these observations, we propose that tRNA precursors operate in the <i>S. pombe</i> TORC1 pathway to switch growth mode from vegetative to reproductive.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29330317</PMID><DateCompleted><Year>2019</Year><Month>02</Month><Day>05</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1469-3178</ISSN><JournalIssue CitedMedium="Internet"><Volume>19</Volume><Issue>3</Issue><PubDate><Year>2018</Year><Month>03</Month></PubDate></JournalIssue><Title>EMBO reports</Title><ISOAbbreviation>EMBO Rep</ISOAbbreviation></Journal><ArticleTitle>tRNA production links nutrient conditions to the onset of sexual differentiation through the TORC1 pathway.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">e44867</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.15252/embr.201744867</ELocationID><Abstract><AbstractText>Target of rapamycin (TOR) kinase controls cell growth and metabolism in response to nutrient availability. In the fission yeast <i>Schizosaccharomyces pombe,</i> TOR complex 1 (TORC1) promotes vegetative growth and inhibits sexual differentiation in the presence of ample nutrients. Here, we report the isolation and characterization of mutants with similar phenotypes as TORC1 mutants, in that they initiate sexual differentiation even in nutrient-rich conditions. In most mutants identified, TORC1 activity is downregulated and the mutated genes are involved in tRNA expression or modification. Expression of tRNA precursors decreases when cells undergo sexual differentiation. Furthermore, overexpression of tRNA precursors prevents TORC1 downregulation upon nitrogen starvation and represses the initiation of sexual differentiation. Based on these observations, we propose that tRNA precursors operate in the <i>S. pombe</i> TORC1 pathway to switch growth mode from vegetative to reproductive.</AbstractText><CopyrightInformation>© 2018 The Authors.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Otsubo</LastName><ForeName>Yoko</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Laboratory of Cell Responses, National Institute for Basic Biology, Okazaki, Aichi, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matsuo</LastName><ForeName>Tomohiko</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Tokyo, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nishimura</LastName><ForeName>Akiko</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Tokyo, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yamamoto</LastName><ForeName>Masayuki</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Laboratory of Cell Responses, National Institute for Basic Biology, Okazaki, Aichi, Japan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Tokyo, Japan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Basic Biology, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), Okazaki, Aichi, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yamashita</LastName><ForeName>Akira</ForeName><Initials>A</Initials><Identifier Source="ORCID">0000-0002-1805-1434</Identifier><AffiliationInfo><Affiliation>Laboratory of Cell Responses, National Institute for Basic Biology, Okazaki, Aichi, Japan ymst@nibb.ac.jp.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Basic Biology, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), Okazaki, Aichi, Japan.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>01</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>EMBO Rep</MedlineTA><NlmUniqueID>100963049</NlmUniqueID><ISSNLinking>1469-221X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>9014-25-9</RegistryNumber><NameOfSubstance UI="D012343">RNA, Transfer</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="D000076222">Mechanistic Target of Rapamycin Complex 1</NameOfSubstance></Chemical><Chemical><RegistryNumber>N762921K75</RegistryNumber><NameOfSubstance UI="D009584">Nitrogen</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D049109" MajorTopicYN="N">Cell Proliferation</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015966" MajorTopicYN="N">Gene Expression Regulation, Fungal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000076222" MajorTopicYN="N">Mechanistic Target of Rapamycin Complex 1</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009584" MajorTopicYN="N">Nitrogen</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000078622" MajorTopicYN="N">Nutrients</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010766" MajorTopicYN="N">Phosphorylation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012343" MajorTopicYN="N">RNA, Transfer</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012568" MajorTopicYN="N">Schizosaccharomyces</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000254" MajorTopicYN="Y">growth & development</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012733" MajorTopicYN="N">Sex Differentiation</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">TORC1</Keyword><Keyword MajorTopicYN="Y">fission yeast</Keyword><Keyword MajorTopicYN="Y">sexual differentiation</Keyword><Keyword MajorTopicYN="Y">tRNA precursor</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>07</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>11</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>12</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>1</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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Yamamoto</name><name sortKey="Yamamoto, Masayuki" sort="Yamamoto, Masayuki" uniqKey="Yamamoto M" first="Masayuki" last="Yamamoto">Masayuki Yamamoto</name><name sortKey="Yamamoto, Masayuki" sort="Yamamoto, Masayuki" uniqKey="Yamamoto M" first="Masayuki" last="Yamamoto">Masayuki Yamamoto</name><name sortKey="Yamashita, Akira" sort="Yamashita, Akira" uniqKey="Yamashita A" first="Akira" last="Yamashita">Akira Yamashita</name><name sortKey="Yamashita, Akira" sort="Yamashita, Akira" uniqKey="Yamashita A" first="Akira" last="Yamashita">Akira Yamashita</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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